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FORMULATION AND EVALUATION OF FAST DISSOLVING GRANISETRON HYDROCHLORIDE TABLETS: EFFECT OF FUNCTIONALITY OF SUPERDISINTEGRANTS

BASAWARAJ S PATIL, N.G. Raghavendra Rao

Abstract


Fast dissolving tablets (FDT) of Granisetron hydrochloride were prepared by direct compression method after incorporating superdisintegrants croscarmellose sodium and crospovidone in different concentrations (2.5, 5, 7.5 and 10 mg). Eight formulations having superdisintegrants at different concentration level were prepared to assess their efficiency and critical concentration level. Different type of evaluation parameters for blends and tablets were used. The prepared tablets were characterized by FTIR studies. No chemical interaction between drug and exciepients was confirmed by FTIR studies. The formulation GCS4 containing croscarmellose sodium showed superior in vitro, in vitro dispersion time and drug release, as compared to other formulations. GCS4 tablet showed good dissolution efficiency and rapid dissolution.  The 50% and 90% of drug release of tablet GCS4, was found within 0.45 and 2.59 min.


References


Zhang Y, Law, Y, and Chakrabarti S. Physical Properties and Compact Analysis of Commonly Used Direct Compression Binders. AAPS Pharm. Sci. Tech. 2003; 4(4): 1-11.

Yasmeen R, Shoaib, MH and Khalid H. Comparative Study of Different Formulations of Atenolol. Pak. J. Pharm. Sci. 2005; 18(1): 49.

Beyer T, Day GM and Price SL. The prediction, morphology and mechanical properties of the polymorphs of Paracetamol. J. Am. Chem. Soc. 2001; 123: 5086-5094.

Shangraw RF. In: Liberman HA, Lachman L and Schwartz JB editors. Pharmaceutical Dosage Forms: Tablets, Vol. 01, Mercel Dekker, Inc., New York, 1989; pp.109-164.

Ibrahim and Olurinola. Comperative microbial contamination levels in wet granulation and direct compression methods of tablet production. Pharm. Acta. Helv. 1991; 66: 293-301.

Gohel MC. A review of Co-processed Directly compressible excipients. J. Pharm. Sci, 2005;8(1): 76-93.

Jivraj M, Martini LG. and Thomson CM. An overview of different excipients useful for the direct compression of tablets. Pharm. Sci. Technol. 2000; 3(2): 58-63.

Sanger GJ and Nelson PR. Selective and functional 5-Hydroxytryptamine 3 receptor antagonism, Eur. J. Pharmacol. 1989; 159: 113-124.

Upward JW, Amold BDC, Link C, Pieree DM, Allen A and Tasker TCG. The Clinical Pharmacology of Granisetron, a novel specific 5-HT3 antagonist. Eur. J. Cancer. 1990; 26: S12-S15.

Carmichael J, Cantwell BMJ, Edwards CM, Zussman BD, Thomson S, Rapeport WG and Harris AL. A pharmacokinetic study of Granisetron, a selective 5-HT3 receptor antagonist: correlation with anti-emetic response. Cancer Chemother. Pharmacol. 1989; 24:45-49.

Yunyun Jiang, Mei Lin, Guorong Fan, Yi Chen, Zhe Li, Weiquan Zhao, Yutian Wu and Jinhong Hu. Rapid determination of Granisetron in human plasma by liquid chromatography coupled to tandem mass spectrometry and its application to bioequivalence study. J. Pharm. & Biomed. Anal. 2006. (Epub ahead of print).

Aapro M. Granisetron an update on its clinical use in the management of nausea and vomiting. Oncologist. 2004;9:673-686.

Habib W, Khankari R, Hontz J. Fast dissolving drug delivery systems. Crit. Rev. Ther. Drug Carr. Syst. 2000; 17:61-72.

Babu GV, Kumar NR, Himasankar K, Seshasayana A, Murthy KV. Nimesulide-modified gum karaya solid mixtures: Preparation, characterization and formulation development. Drug Dev. Ind. Pharm. 2003; 29:855-864.

Arias MJ, Gines JM, Moyano JR, Perez-Martinez JI, Rabasco AM. Influence of preparation method of solid dispersions on dissoluion rate: study of triammterene-D-mannitol system. Int. J. Pharm. 1995; 123:25-31.

Yunxia B, Sunada H, Yonezawa Y, Danjo K. Evaluation of rapid disintegrating tablets prepared by direct compression method. Drug Dev. Ind. Pharm. 1999; 25:571.

Kuchekar BS, Arumugam V. Fast dissolving tablets. Indian J. Pharm. Edu. 2001; 35:150.

Gohel MC, Parikh RK, Brahmbhatt BK, and Shah AR. Preparation and assessment of novel co processed super disintegrants consisting of crospovidone and sodium starch glycolate: A technical note. AAPS Pharm. Sci. Tech. 2007;8(1): Article 9: P. E1-E7.

Jacob S, Shirwarkar AA, Joseph A, and Srinivasan KK. Novel co-processed excipients of mannitol and microcrystalline cellulose for preparing fast dissolving tablets of glipizide. Indian J. Pharm. Sci. 2007; 69(5): 633-9.

Gohel MC, Parikh RK, Brahmbhatt BK, and Shah AR. Improving the tablet characteristics and dissolution profile of ibuprofen by using a novel co processed superdisintegrant: A technical note. AAPS Pharm. Sci. Tech. 8(1): Article 2007; 13, P. E1-E6.

Musa E, Ala’s E, Iyad R, Mayyas A, and Adnan Badwan. A novel superdisintegrating agent made from physically modified chitosan with silicon dioxide. Drug Dev and Ind. Pharm . 2008;34: 373-83.


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