Effect of Momordica charantia Linn. leaf and fruit juice on fertility in male mice

Ampa Luangpirom, Watchara Kourchampa, Pichet Somsapt

Abstract


Fertility effect of Momordica charantia Linn. leaf and fruit juice at doses of 200, 400 and 600 mg/ 100 gBW were evaluated by determining blood prolactin (PRL) and testosterone (T) levels, and sperm quality in male mice after 21 days of oral administration.  The increase in PRL and decrease in T levels were found to be dose dependent in both treatments.  Meanwhile, the sperm quality impairment was found in group receiving fruit juice was more severe than that of groups receiving leaf juice. Interestingly, the potency of testicular dysfunction was related to the degree of alteration of reproductive hormones. In conclusion, M. charantia leaf and fruit juice may cause testicular dysfunction, which indirectly affects pituitary PRL synthesis and consequently impaired testicular T synthesis. The use of M. charatia products at high dose in traditional medicine should include a caution about this adverse effect, especially in long term treatment.


Keywords


Momordica charantia Linn.; fertility; prolactin; testosterone

Full Text:

PDF

References


Smitinand T & Santisuk T, Cucurbitacea. In: Flora of Thailand. Vol 9, Part 3, 2008, pp:464-465. [2] Grover JK & Yodav SP, Pharmacological actions and potential uses of Momordica

charantia: A review, J Ethnopharmacol, 2004, 93: 123-132.

Paul A & Raychandluri SS, Medicinal uses and molecular identification of two

Momordica charantia varieties, Electronic J Biol, 2010. 6: 43-51. [4] Kumar DS, Sharathnath KV, Yongeswaran P, Haran A, Sudhakar K, Sudha P & Banji D,

A medicinal potency of Momordica charantia, Int J Pharm Sci Rev Res, 2010, 1: 95-100. [5] Michael B, Krawinkle MB & Keding GB, Bitter gourd (Momordica charantia): A dietary

approach to hypoglycemia, Nutrition, 2006, 64: 331-337. [6] Belion N, Gbeassor M, Akpagana K, Hudson J, De Soussa K, Koumaglo K & Arnason

JT, Ethnomedical uses of Momordica charantia (Cucurbitaceae) in Togo and relation to

Its phytochemistry and biological activity, J Ethnopharmacol, 2005, 96 : 49-55. [7] Kohno H, Yasui Y, Suzuki R, Hosokawa M, Miyashita K, Koumaglo K & Arnason JT,

Dietary seed oil in conjugated linoleic acid from bitter melon inhibits zoxymethane

induced rat colon carcinogenesis through elevation of colonic PPAR gamma expression

of lipid composition, Inter J Cancer, 2004, 110: 896-901. [8] Gadang V, Gilbert W, Heltiarchechy N, Horax R, Katwa L & Devareddy L, Dietary bitter

melon seed increases peroxisome proliferator-activated receptor gamma gene expression

in adipose tissue, down regulates the nucleus factor-LB expression, and alleviates the

symptoms associated with metabolic syndrome, J Med food, 2011, 14: 86-90. [9] Stepka W, Wilson KE & Madge GE, Antifertility investigation on Momordica charantia,

Lloydia, 1974, 34: 645-648. [10] Dixit VP, Khanna P & Bhargava SK, Effect of Momordica charantia L. fruit extract on

the testicular function of dog, Planta Med, 1978, 34: 280-286. [11] Naseem MZ, Patil SR, Patil SR, Ravindra & Patil RB, Antispermatogenic and

androgenic activities of Momordica charantia (Karen) in albino rats, J Ethnopharmacol ,

, 61: 9-16. [12] Patil SR & Patil SB, Toxicological studies of Momordica charantia Linn. seed extract in

male mice, Int J Morphol, 2011, 29: 1212-1218. [13] Patil SR., Patil SB & Sadyanarayan ND, Isolation of phytoestrogen from Momordica

charantia seed (bitter melon). Cur Top Nutraceu Res, 2011, 9:61-66. [14] Amah CI, Ebaetre YO, Ikechukwu DF & Adewale OA, Effect of Momordica charantia

on estrus cycle of Sprague –Dawley rats, Pacific J Med Sci, 2011, 8: 38-48 15] Jerald SE, Pandey A, Bigoniya P & Singh S, Antifertility activity of Momordica

charantia descourt pulp and seed hydroalcoholic extract, J Appl Pharm, 2012, 4: 682-696. [16] Uche-Nwachi EO & McEwen C, Teratogenic effect of the water extract of bitter gourd

(Momordica charantia) on the Sprague- Dawley rats, Afr J Trad Comple Alter Med,

, 7: 24-33. [17] Yokoi K, Uthus EO & Nielsen FH, Nickel deficiency diminishes sperm quality and

movement in rats, Biol Trace Elem Res, 2003, 93; 141-154. [18] Sonmez M, Yuce A &Turk G, The protective effect of melatonin and vitamin E on

antioxidant enzyme activities and epidimal sperm characteristics of homocysteine

treated male rats, Reprod Toxicol, 2007, 23:226-231.

Atessahin A, Turk G, Karaham I, Yilmaz S, Ceribast AO & Bulmus O, Lycopene

prevents adriamycin -induced testicular toxicity in rats, Fertil Steril, 2006, 85: 1216-

. [20] Zar JH, Biostatistical analysis: 5th edition, Pearson Prentice Hall, Inc, New Jercy, USA, 2

,189-248. [21] MaCallum RW, Sowers JR, Hershman JM & Sturdevant RA, Metoclopramide stimulates

prolactin secretion in man, J Clin Endocrinol Metab, 1976, 42: 1148-1151. [22] Freeman MF, Kanyicaka B, Lerant R & Naggy G, Prolactin: structure, function and

regulation of secretion, Physiol Rev, 2000, 80: 1523-1585. [23] Luboshitzky R., Rosen E, Trestian S & Spitz IM, Hyperprolactinemia and

hypogonadism in men: response to exogenous gonadotropins, Clin Endocrinol, 1979, 11:

-223. [24] Murray FT, Cameron DF & Ketchum C, Return of gonadal function in men with

prolactin-secreting pituitary tumors, J Endocrinol Metab, 1984, 59: 79-85. [25] Segal S, Yaffe H, Laufer N & Ben-David M, Male hyperprolactinemia effects on

fertility, Fertil Steril, 1979, 32: 556-561. [26] Winter JJ.& Troen P, Altered pulsatile secretion of luteinizing hormone in hypogonadal

men with hyperprolactinemia, Clin Endocrinol, 2008, 21: 257-263. [27] Chandra AK, Sengupta P, Goswami H & Sarkar M, Excessive dietary calcium in the

disruption of structural and functional status of adult male reproductive system in rat

with possible mechanism. Mol Cell Bioch, 2012, 364: 181-191. [28 ] Sorensen AMJ, Animal reproduction principle and practices, 1979, Graw-Hill, USA. [29] Craft J, Bennet V & Nicholson N, Fertilising ability of testicular spermatozoa, Lancet,

, 342: 864-869.


Refbacks

  • There are currently no refbacks.
';



Copyright (c) 2015 International Journal of Phytomedicine

Advanced Research Journals

18K, Street 1st, Gaytri Vihar, Pinto Park, Gwalior, M.P. India

Copyright@arjournals.org (Design) 2009-2017

 

Follow @arjournals on Twitter