Effect of Carum carvi and Curcuma longa on hormonal and reproductive parameter of female rats

Abstract

Rhizome of Curcuma longa and seeds of Carum Carvi a folk medicinal plant used as have antifertility potentials. Present investigation study the effect of both the plant on hormone and reproductive parameter of female rat. The aqueous and ethanolic extract of rhizome of Curcuma longa and seeds of Carum Carvi used for testing antifertility activity in female rat. Aqueous and ethanolic extract of plants were administered orally to female rat for 30 consecutive days. Estrous cycle, reproductive hormones (LH, FSH and estrogen) and weight of reproductive organ were studied in both control and extract-administered groups by using standard methods. The female albino rats after oral administration of different doses of aqueous and ethanolic extracts of Carum carvi and Curcuma longa, showed a significant antifertility activity. FSH and LH level was significantly decreased in both drugs while amount of estrogen in ethanolic extract of both the drugs treated animals was found to be increased.The blockage of estrus phase induced by treatment of aqueous and ethanolic extract of both drug. They also increase the weight of ovary, uterus and body weights while uterine weight in immature rats increased in extract treated group. The present study which was undertaken to find endocrinological and physiological changes in the reproductive system of female albino rats after oral administration of different doses of aqueous and ethanolic extracts of Carum carvi and Curcuma longa, showed a significant antifertility activity.

Keywords: Antifertility; Estrogenic, Reproductive, Curcuma longa and Carum carvi