Antidiabetic, hypolipidaemic and antioxidant activity of Dodonaea viscosa aerial parts in streptozotocin-induced diabetic rats

V.P. Veerapur, K.R. Prabhakar, Vipan Kumar Parihar, Punit Bansal, K.K. Srinivasan, K.I. Priyadarsini, M.K. Unnikrishnan

Abstract


We evaluated the antidiabetic and antioxidant activity of Dodonaea viscosa in streptozotocin-induced diabetic rats. The water extract (DVW) and polar fraction of ethanol extract (DVE-4) in a single-dose one-day study showed dose-dependent reduction in glucose levels with maximum effect of 42.16% and 72.9% respectively at 6 h post drug treatment (p<0.001). DVE-4 was more active than DVW and glibenclamide. In a multi-dose fifteen-day study, lower doses of DVW (400 mg/kg) and DVE-4 (200 mg/kg) exhibited higher percentage reduction in glucose levels compared to glibenclamide treated group. Altered levels of lipids, TBARS, non-enzymatic and enzymatic antioxidants were restored by DVW (400 mg/kg) and DVE-4 (200 mg/kg) in diabetic rats. In vitro steady state and time resolved studies reveled that DVW and DVE-4 showed comparable antioxidant ability in steady state and kinetic studies suggesting its possible role in observed antidiabetic and hypolipidaemic activities.

Keywords: Antidiabetic, Antioxidant enzymes, Dodonaea viscosa, Free radical scavenger, Hypolipidaemic, Streptozotocin


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DOI: http://dx.doi.org/10.5138/ijpm.v2i1.89

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