Anti-inflammatory and analgesic activity of different fractions of Boswellia serrata

A. Sharma, S. Bhatia, M. D. Kharya, V. Gajbhiye, N Ganesh, A. G. Namdeo, K. R. Mahadik

Abstract


The study was designed to investigate the anti-inflammatory and analgesic effect of different fractions of Boswellia serrata. The effect of different fractions of Boswellia serrata were studied using carrageenan induced paw edema, acetic acid induced writhing response, formalin induced pain, hot plate and tail flick method for studying anti-inflammatory and analgesic activity, respectively. The different fractions of B. serrata, essential oil (10 ml/kg), gum (100 mg/kg, resin (100 mg/kg) oleo-resin (100 mg/kg) and oleo-gum-resin (100 mg/kg) significantly reduces carrageenan induced inflammation in rats and shows analgesic activity, as determined by acetic acid induced writhing response, formalin induced pain, hot plate and tail flick method. The different fractions of B. serrata showed prompt anti-inflammatory and analgesic activity due to the inhibition of 5-lipoxygenase enzyme.

Keywords: Analgesic; Boswellia serrata; Inflammation; 5- lipoxygenase; Burseraceae.


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DOI: http://dx.doi.org/10.5138/ijpm.v2i1.93

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