The Queen of Herb with Potent Therapeutic Constituent in Various Disease States: A Reappraisal

Md Harun Al Rashid, Anindya Banerjee, Nigam Jyoti Maiti

Abstract


Ocimum sanctum Linn has been used extensively for its medicinal value in India and China. In traditional system of medicine, different parts (leave, stem, flower, root, seed and even whole plant) of O. sanctum L. (Tulsi in Hindi and Vasub in Arabic), a small herb seen throughout in India. O. sanctum have been recommended for the treatment of bronchitis, bronchial asthma, malaria, diarrhea, dysentery, skin disease, arthritis, painful eye disease, chronic fever, insect bite etc. It has also been suggested to possess antifertility, anticancer, antidiabetic, antifungal, antimicrobial, hepatoprotective, cardio-protective, antiemetic, antispasmodic, adoptogenic and diaphoretic activity.

Current scientific research revealed  that O. sanctum exhibit significant anticancer activity by enhancing antioxidant potential of gastric mucosa thereby reducing mucosal damage and reduces  stress; enhances  stermina and endurance ;boosts the immune system, reduces inflammation; lessens aging factors; supports the heart, lungs and liver.

Keywords


Tulsi, NF-κB, TNF-α, antioxidant, anticancer, anthelmentic

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References


. Warrier P.K., In: ongman O, editor. Indian Medical Plants. New Delhi, CBS publication, 1995. P-168.

. Indial J physiol pharmacol 2005; 49(2) Therapeutic Uses of O. sanctum Linn (Tulsi) 13

. (Edited and published by S, Cipla Ltd., Bombay Central, Bombay), Ocimum sanctum: The Indian home remedy. In: Current Medical Scene, March-April 1992

. Gazzaneo, Ir., Paira de licena, R.F. and Paulino de Albuquerque.: J Ethnobiol. Ethnomed. 1:9 (2005).

. Singh, N.K. and Sehgal C.B., Micropropagation of “Holly basil”(Ocimum sanctum Linn.) from young inflorescence of nature plants. Plants Growth Regul., 1999. 29(5):161-166.

. Sen P. Therapeutic Potential of Tulsi: From experience to facts. Drugs News View 1993,1:15-21

. Gupta SK, Prokash J, Srivastav S. Validation of traditional claim of Tulsi, Ocimum sanctum Linn as a medicinal Plant. Indian J Exp Biol 2002 40;765-73

. Chopra RN, Nayer SI, Chopra IC. Glossary of Indian Medicinal plant. New Delhi CSIR;1956

. Kokate C.K., Purohit A.P., Gokhale S.B. Pharmacognosy 2009: P-11.53

. Yanpallewar SU, Rai S,Kumar M, Acharya SB. Evaluation of antioxidant and neuroprotective effect of Ocimum sanctum on transient cerebral ischemia and long term cerebral hypoperfusion. Bhamacol Biochem Behar 79(1): 2004, 155-164.

. Gupta SK, Prokash J, Srivastav S. Validation of traditional claim of Tulsi, Ocimum sanctum Linn as a medicinal Plant. Indian J Exp Biol 2002 40;765-73

. Shah CS, Qadry JS. A Test Book of Pharmacognosy 1998: P-216

. Kokate C.K., Purohit A.P., Gokhale S.B. Pharmacognosy 2009: P-11.53

. Maimes Report of Holy basil. Ocimum sanctum-Tulsi: version 1-November 2004-www.holy-basil.com.

. Eliningaya J. Kweka1, Hassan M. Nkya, Lucile Lyaruu, Epiphania E. Kimaro, Beda J. Mwang’onde,Aneth M. Mahande. Efficacy of Ocimum kilimandscharicum plant extracts after four years of storage against Anopheles gambiaess. Journal of Cell and Animal Biology 2009; 3:171-174

. Raja R. and Ratnam Prasad. Chemo types of Ocimum: Exploring the Potential of Pathway Engineering

. Karthikeyan, P. Gunasekaran, N. Ramamurthy and S. Gobindasamy: Anticancer activity of Ocimum sanctum Summary Pharmaceutical Biology 1999. Volume 37, No.4 pages 285-290.

. Kath R K & Gupta R K. Antioxidant activity of hydroalcoholic leaf extract of Ocimum sanctum in animal models of peptic ulcer. Indian J Physiol Pharmacol 2006, 50 (4): 391–396

. Kochhar A, Sharma N and Sachdeva R. Effect of Supplementation of Tulsi (Ocimum sanctum) and Neem (Azadirachta indica) Leaf Powder on Diabetic Symptoms, Anthropometric Parameters and Blood Pressure of Non Insulin Dependent Male Diabetics. Ethno-Med 2009, 3(1): 5-9

. Madhuri Sharma and Pandey Govind. Ethnomedicinal plants for prevention and treatment of tumours 2009, 3 (1):2-5.

. Misra P?, Pal NL, Guru P K, Katiyar J C and Tandon J S. Antimalarial Activity of Traditional Plants against Erythrocytic Stages of Plasmodium berghei. Pharmaceutical Biol. Vol. 29(1): 19-23, 1991

. Mandan S, Das D N, Kamala D, Ray K, Roy G, Chaudhari SB, Sahana. Ocimum sanctum Linn – A study on gastric ulceration and gastric secretion in rats. Indian J Physiol Pharmacol 1993, 37: 91–92

. Nair V D, Jaleel CA, Gopi R, Gomathinayagam M, Panneerselvam R. Antioxidant potential of Ocimum sanctum under growth regulator treatments. EurAsia J BioSci 2009; 3: 1-9.

. Halder N, Joshi N, Gupta SK. Lens aldose reductase inhibiting potential of some indigenous plants. J Ethnopharmacol 86(1):2003,113-116.

. Misra P?, Pal NL, Guru P K, Katiyar J C and Tandon J S. Antimalarial Activity of Traditional Plants against Erythrocytic Stages of Plasmodium berghei. Pharmaceutical Biol. Vol. 29(1): 19-23, 1991.

. Ahmed M, Ahamed RN, Aladakatti RH, Ghosesawar MG. Reversible anti-fertility effect of benzene extract of Ocimum sanctum leaves on sperm parameters and fructose content in rats. J Basic Clin Physiol Pharmacol. 2002; 13(1):51-9.

. Pratibha D. Nadig and Laxmi S. Study of anti-tussive activity of Ocimum sanctum Linn in guinea pigs. Indian J Physiol Pharmacol 2005, 49 (2): 243–245.

. Seth SD, Johri N, Sundaram KR. Antispermatogenic effect of Ocimum sanctum. Indian J Exp Biol 19:1981,975.

. Madhuri S. Studies on oestrogen induced uterine and ovarian carcinogenesis and effect of ProImmu in rats. PhD thesis, Rani Durgavati Vishwa Vidyalaya, Jabalpur, MP, India: 2008.

. Madhuri S., Pandey Govind. Effect of ProImmu, a herbal drug on estrogen caused uterine and ovarian of tumor promotion in mice by eugenol. Indian J Physiol Pharmacol 38:1994,306.

. Pandey Govind. An overview on certain anticancer natural products. J Pharm Res 2(12):2009, 1799-1803.

. Pandey Govind, Madhuri S. Autochthonous herbal products in the treatment of cancer. Phytomedica 7:2006, 99-104.

. Nakamura C V, Ishida K, Faccin L C, Filho B P D, Cortez D A G, Rozental S, de Souza W and Ueda-Nakamura T. In vitro activity of essential oil from Ocimum gratissimum L. against four Candida species. Research in Microbiology 2004, 155(7): 579-586.

. (Edited and published by S, Cipla Ltd., Bombay Central, Bombay), Ocimum sanctum. The Indian home remedy. In: Current Medical Scene 1992.

. Prashar R, Kumar A, Hewer A, Cole KJ, Davis W, Phillips DH. Inhibition by an extract of Ocimum sanctum of 7, 12-dimethylbenz(a)anthracene in rat hepatocytes in vitro. Cancer Lett 128(2):1998,155-160.

. Panda S and Kar A. Ocimum sanctum leaf extract in the regulation of thyroid function in the male mouse. Pharmacol Res 1998, 38(2): 107–110.

. Uma Devi P, Gonasoundari A. Radioprotective effect of leaf extract of Indian Medicinal Plant Ocimum sanctum. Indian J Exp Biol 33:1995, 205.

. Uma Devi P, Gonasoundari A, Vrinda B, Srinivasan KK, Unnikrishanan MK. Radiation protection by the Ocimum sanctum flavonoids orientin and vicenin: Mechanism of action. Radiat Res 154(4): 2000, 455-460.

. Saija A, Scalese M, Lanza M, Marzillo D, Bonina F, Castelli F. Flavonoids as antioxidant agents: Importance of their interaction with biomembrane. Free Rad Biol Med 19:1995, 481.

. Kelm MA, Nair MG, Strasburg GM, DeWitt DL. Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine. 7(1):2000, 7-13.

. Nair AGR, Gunasegaran R, Joshi BS. Chemical investigation of certain south Indian plants. Indian J Chem 21B:1982, 979.

. Sood S, Narang D, Thomas MK, Gupta YK, Maulik SK. Effect of Ocimum sanctum Linn. On cardiac changes in rats subjected to chronic restraint stress. J Ethnopharmacol 2006; 108:423-7.

. Singh S, Malhotra M, Majumdar DK. Antibacterial activity of Ocimum sanctum L. fixed oil. Indian J Exp Biol 43:2005, 835.

. Joglekar GV, Chaudhary NY & Aiman R. Effect of indigenous plant extracts on glucose-absorption in mice. Indian Journal of Physiology and Pharmacology 1959, 3: 76

. Jyoti S, Satendra S, Sushma S, Anjana T, Shashi S. Antistressor activity of Ocimum sanctum (Tulsi) against experimentally induced oxidative stress in rabbits. Methods Find Exp Clin Pharmacol. 2007, 29(6):411-6.

. Chiang L C, Ng L T, Cheng P W, Chiang W & Lin C. Antiviral activities of extracts and selected pure constituents of Ocimum basilicum. Clinical and Experimental Pharmacology and Physiology 2005, 32(10): 811-816.

. Seethalakshmi B, Narasappa AP, Kenchaveerappa S. Protective effect of Ocimum sanctum in experimental liver injury in albino rats. Indian J Pharmacol,14:1982, 63.

. Chattopadhyay RR, Sarkar SK, Ganguly S, Medda C, Basu TK. Hepatoprotective activity of O. sanctum leaf extract against paracetamol induced hepatic damage in rats. Indian J Pharmacol. 24:1992, 163.

. Singh S, Taneja M, Majumdar DK. Biological activities of Ocimum sanctum L. fixed oil- An overview. Indian J Exp Biol 45:2007, 403-412.

. Reghunandana R et al. (1995). Effect of Ocimum sanctum Linn (Tulsi) extract on testicular function. Indian J Medical Research 1995, 49(4):83–87.

. Godhwani S, Godhwani JL, Vyas DS. Ocimum sanctum: A preliminary study evaluating its immunoregulatory profile in albino rats. J Ethnopharmacol 24:1988,193-198.

. Rastogi S. Ayurveda for comprehensive healthcare.Indian J. Med. Ethics 2009, 6(2):101-102.

. Khanna N, Bhatia J. Antinociceptive action of Ocimum sanctum (Tulsi) in mice: Possible mechanisms involved. J Ethnopharmacol 2003; 88:293-6.

. Singh S, Taneja M, Majumdar DK. Biological activities of Ocimum sanctum L. fixed oil- An overview. Indian J Exp Biol 45:2007, 403-412.

. Kelm MA, Nair MG, Stasburg GM, DeWitt DL. Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn. Phytomedicine 2000; 7:7-13.

. Asha MK, Prashanth D, Murali B, Padmaja R, Amit A. Anthelmintic activity of essential oil of Ocimum sanctum and eugenol. Fitoterapia 2001; 72:669-70.

. Mukherjee R, Dash P K, Ram G C. Immunotherapeutic potential of Ocimum sanctum (L) in bovine subclinical mastitis. Res Vet Sci 2005; 79:37-43.

. Singh S, Majumdar DK. Effect of fixed oil of Ocimum sanctum against experimentally induced arthritis and joint edema in laboratory animals. Int J Pharmacog 34:1996, 218.

. Singh S, Rehan HMS, Majumdar DK. Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time. J Ethnopharmacol 78:2001, 139.

. Shetty S, Udupa S, Udupa L, Somayaji N. Wound healing activity of Ocimum sanctum Linn with supportive role of antioxidant enzymes. Indian J Physiol Pharmacol 2006; 50:163-8.

. Trevisan MT, Vasconcelos Silva MG, Pfundstein B, Spiegelhalder B, Owen RW. Characterization of the volatile pattern and antioxidant capacity of essential oils from different species of the genus Ocimum. J Agric Food Chem 2006; 54:4378-82.

. Pandey BP and Anita. In: Economic Botany (Published by Chand and Company Ltd., Ramnagar, New Delhi), p. 294. 1990.

. Seth S D, Johri N, Sundaram K R. Antispermatogenic effect of Ocimum sanctum. Indian J Exp Biol 1981; 19:975-6.

. Kasinathan S, Ramakrishnan S, Basu SL. Antifertility effect of Ocimum sanctum L. Indian J Exp Biol 1972;10:23-5.

. Brinker F. Herb Contraindications and Drug Interactions. New York, Eclectic Medical Publications; 1998. p.33.


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